**** Important note for System Administrators ****
If you are like many Windows Server SysAdmins, you likely have a comprehensive anti-virus/spyware system in place, and that great and you can prob mostly disregard this.
However, if you are fairly new to the Windows Server platform (2012, 2012R2, 2014, and the Upcoming 2016) - you may wish to take note, a serious one.
So you've prob gone through the normal checklist items: Firewall, Check - Latest Security Updates, Check - and then you have a desktop user in your enterprise that clicks on one of those pesky click-baits, email scams, etc... and bamn - they gain/win some spyware and things get cleared up pretty quickly.
But... what if its smart enough to meander across your network and make it to one of your newly installed Windows Servers - at this time you may be surprised to find out you don't have ANY AV/Spyware protection on your server and it gets compromised. You quickly go to download one of your favorite free (approved) items - AVG, Avast, Comodo..uh oh, it doesn't seem to work on your version of OS (Server).
So you go to download the trusty MS Security Essentials, click install, and are met with a similar warning..."(red x) Microsoft Security Essentials cannot be installed on your operating system" - oh crap!
So what do you do now? Well, there happens to be a fairly easy and efficient work-around for this solution, here is how to do it:
- Download a copy of MSE from Microsoft: http://windows.microsoft.com/…/security-essentials-all-vers…
- Right Click on the mseinstall.exe.
- Click on Properties.
Click on the Compatibility tab.Locate the Compatibility section.
6. Check Run this program in compatibility mode for
7. Select From the drop down menu Windows 7
8. Open a Command Prompt as Administrator. 
9. Navigate to your Downloads folder (ie. cd C:Users%username%Downloads / cd C:\Users\insert-username\Downloads).
10. Run mseinstall /disableoslimit and follow the installer prompts to install MSE on your Windows Server 2012.
All fixed up! Now that wasn't so hard, and now you can return to breathing....and going ahead to run the scan you've been wanting to all along, and remove that pesky spyware once and for all and return to "hero-status".